In recent years, China, U.S.A, Canada, Japan and other countries have carried out the natural gas hydrate (NGH) exploitation for many times in multiple types of NGH reservoirs in different sea areas. However, the results show that the problem of sand plugging is still a key factor restricting its long-term efficient exploitation. In this paper, based on the NGH reservoir characteristics and the sand production mechanism analysis in Shenhu sea area, the practice experiences of sand control in loose sandstone reservoirs and the sand control experiences of NGH reservoir exploration in Shenhu sea area (2017 and 2020)，the limitations of the existing technology of screen completion in NGH reservoirs with argillaceous siltstone have been analyzed and studied extensively and deeply.The design concept of "self-cleaning" precise micropore composite screen (PMC) is proposed for the first time, its self-cleaning principle and the application prospect are analyzed and explained, and the screen size and screening accuracy are optimized. Meanwhile, the structure, material, slotting type, and the periodic sand plugging removal of the sand flushing pipe, which is the core component of the new PMC, is also discussed in this paper. Finally, this research focusing on "self-cleaning" sand control screen is an innovative exploration of long-term sand control completion, which will help to promote the development process of NGH reservoir.